Association of polymorphisms in LEPR with type 2 diabetes and related metabolic traits in a Chinese population.

ABSTRACT:

Background

Leptin acts as a mediator of inflammation and energy homeostasis by activating leptin receptor (LEPR). We conducted this study to explore the association of polymorphisms in LEPR with type 2 diabetes mellitus (T2DM) and its related metabolic traits.

Methods

We performed a case-control study to investigate the association of polymorphisms in LEPR with T2DM and related metabolic traits in a Chinese population, with a total of 922 T2DM patients and 1031 nondiabetic subjects. Polymorphisms were genotyped using MassARRAY assay.

Results

The G allele of rs1327118 was associated with a decreased risk of T2DM in men (P = 0.044, odds ratio = 0.707, 95% confidence interval = 0.504-0.991) and the G allele of rs3806318 was associated with increased systolic blood pressu

SUBMITTER: Zhang L 

PROVIDER: S-EPMC5753482 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature