The variome of pneumococcal virulence factors and regulators.

ABSTRACT:

Background

In recent years, the idea of a highly immunogenic protein-based vaccine to combat Streptococcus pneumoniae and its severe invasive infectious diseases has gained considerable interest. However, the target proteins to be included in a vaccine formulation have to accomplish several genetic and immunological characteristics, (such as conservation, distribution, immunogenicity and protective effect), in order to ensure its suitability and effectiveness. This study aimed to get comprehensive insights into the genomic organization, population distribution and genetic conservation of all pneumococcal surface-exposed proteins, genetic regulators and other virulence factors, whose important function and role in pathogenesis has been demonstrated or hypothesized.

Results

Af

SUBMITTER: Gamez G 

PROVIDER: S-EPMC5753484 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature