Long interspersed nuclear element-1 expression and retrotransposition in prostate cancer cells.

ABSTRACT:

Background

Long Interspersed Nuclear Element-1 (LINE-1) is an autonomous retrotransposon that generates new genomic insertions through the retrotransposition of a RNA intermediate. Expression of LINE-1 is tightly repressed in most somatic tissues to prevent DNA damage and ensure genomic integrity. However, the reactivation of LINE-1 has been documented in cancer and the role of LINE-1 protein expression and retrotransposition has become of interest in the development, progression, and adaptation of many epithelial neoplasms, including prostate cancer.

Results

Here, we examined endogenous LINE-1 protein expression and localization in a panel of prostate cancer cells and observed a diverse range of LINE-1 expression patterns between cell lines. Subcellular localization of LINE

SUBMITTER: Briggs EM 

PROVIDER: S-EPMC5753491 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature