Analysis of microarrays of miR-34a and its identification of prospective target gene signature in hepatocellular carcinoma.

ABSTRACT:

Background

Currently, some studies have demonstrated that miR-34a could serve as a suppressor of several cancers including hepatocellular carcinoma (HCC). Previously, we discovered that miR-34a was downregulated in HCC and involved in the tumorigenesis and progression of HCC; however, the mechanism remains unclear. The purpose of this study was to estimate the expression of miR-34a in HCC by applying the microarray profiles and analyzing the predicted targets of miR-34a and their related biological pathways of HCC.

Methods

Gene expression omnibus (GEO) datasets were conducted to identify the difference of miR-34a expression between HCC and corresponding normal tissues and to explore its relationship with HCC clinicopathologic features. The natural language processing (NLP),

SUBMITTER: Ren FH 

PROVIDER: S-EPMC5753510 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature