Effect of genetic variation in UGT1A and ABCB1 on moxifloxacin pharmacokinetics in South African patients with tuberculosis.

ABSTRACT:

Aim

We assessed the effect of genetic variability in UGT1A and ABCB1 genes on moxifloxacin pharmacokinetics.

Methods

Genotypes for selected UGT1A and ABCB1 SNPs were determined using a TaqMan^® Genotyping OpenArray^™ and high-resolution melt analysis for rs8175347. A nonlinear mixed-effects model was used to describe moxifloxacin pharmacokinetics.

Results

Genotypes of UGT1A SNPs, rs8175347 and rs3755319 (20.6% lower and 11.6% increased clearance, respectively) and ABCB1 SNP rs2032582 (40% reduced bioavailability in one individual) were significantly associated with changes in moxifloxacin pharmacokinetic parameters.

Conclusion

Genetic variation in UGT1A as represented by rs8175347 to a lesser extent rs3755319 and the ABCB1 rs2032582 SNP is m

SUBMITTER: Naidoo A 

PROVIDER: S-EPMC5753622 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature