Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M₄ Muscarinic Receptor.

ABSTRACT: Cholinergic regulation of dopaminergic inputs into the striatum is critical for normal basal ganglia (BG) function. This regulation of BG function is thought to be primarily mediated by acetylcholine released from cholinergic interneurons (ChIs) acting locally in the striatum. We now report a combination of pharmacological, electrophysiological, optogenetic, chemogenetic, and functional magnetic resonance imaging studies suggesting extra-striatal cholinergic projections from the pedunculopontine nucleus to the substantia nigra pars reticulata (SNr) act on muscarinic acetylcholine receptor subtype 4 (M₄) to oppose cAMP-dependent dopamine receptor subtype 1 (D₁) signaling in presynaptic terminals of direct pathway striatal spiny projections neurons. This induces a tonic

SUBMITTER: Moehle MS 

PROVIDER: S-EPMC5753765 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature