Profiling novel metabolic biomarkers for Parkinson's disease using in-depth metabolomic analysis.

ABSTRACT:

Objective

To profile the amine/phenol submetabolome to determine potential metabolite biomarkers associated with Parkinson's disease (PD) and PD with incipient dementia.

Methods

At baseline of a 3-wave (18-month intervals) longitudinal study, serum samples were collected from 42 healthy controls and 43 PD patients. By wave 3 (year 3), 16 PD patients were diagnosed with dementia and were classified as PD with incipient dementia at baseline. Metabolomic profiling using dansylation isotope labeling liquid chromatography mass spectrometry was conducted to compare controls with the full PD, PD with no dementia, and PD with incipient dementia groups.

Results

Metabolomic analyses detected 719 common metabolites in 80% of the samples. Some were significantly altered in pairwi

SUBMITTER: Han W 

PROVIDER: S-EPMC5753769 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature