The Evolution of Gene-Specific Transcriptional Noise Is Driven by Selection at the Pathway Level.

ABSTRACT: Biochemical reactions within individual cells result from the interactions of molecules, typically in small numbers. Consequently, the inherent stochasticity of binding and diffusion processes generates noise along the cascade that leads to the synthesis of a protein from its encoding gene. As a result, isogenic cell populations display phenotypic variability even in homogeneous environments. The extent and consequences of this stochastic gene expression have only recently been assessed on a genome-wide scale, owing, in particular, to the advent of single-cell transcriptomics. However, the evolutionary forces shaping this stochasticity have yet to be unraveled. Here, we take advantage of two recently published data sets for the single-cell transcriptome of the domestic mouse Mus musculu

SUBMITTER: Barroso GV 

PROVIDER: S-EPMC5753856 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature