Functional Redundancy of Variant and Canonical Histone H3 Lysine 9 Modification in Drosophila.

ABSTRACT: Histone post-translational modifications (PTMs) and differential incorporation of variant and canonical histones into chromatin are central modes of epigenetic regulation. Despite similar protein sequences, histone variants are enriched for different suites of PTMs compared to their canonical counterparts. For example, variant histone H3.3 occurs primarily in transcribed regions and is enriched for "active" histone PTMs like Lys9 acetylation (H3.3K9ac), whereas the canonical histone H3 is enriched for Lys9 methylation (H3K9me), which is found in transcriptionally silent heterochromatin. To determine the functions of K9 modification on variant vs. canonical H3, we compared the phenotypes caused by engineering H3.3^K9R and H3^K9R mutant genotypes in <

SUBMITTER: Penke TJR 

PROVIDER: S-EPMC5753860 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature