Local Fitness Landscapes Predict Yeast Evolutionary Dynamics in Directionally Changing Environments.

ABSTRACT: The fitness landscape is a concept that is widely used for understanding and predicting evolutionary adaptation. The topography of the fitness landscape depends critically on the environment, with potentially far-reaching consequences for evolution under changing conditions. However, few studies have assessed directly how empirical fitness landscapes change across conditions, or validated the predicted consequences of such change. We previously evolved replicate yeast populations in the presence of either gradually increasing, or constant high, concentrations of the heavy metals cadmium (Cd), nickel (Ni), and zinc (Zn), and analyzed their phenotypic and genomic changes. Here, we reconstructed the local fitness landscapes underlying adaptation to each metal by deleting all repeatedly mutate

SUBMITTER: Gorter FA 

PROVIDER: S-EPMC5753865 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature