Coalescent Processes with Skewed Offspring Distributions and Nonequilibrium Demography.

ABSTRACT: Nonequilibrium demography impacts coalescent genealogies leaving detectable, well-studied signatures of variation. However, similar genomic footprints are also expected under models of large reproductive skew, posing a serious problem when trying to make inference. Furthermore, current approaches consider only one of the two processes at a time, neglecting any genomic signal that could arise from their simultaneous effects, preventing the possibility of jointly inferring parameters relating to both offspring distribution and population history. Here, we develop an extended Moran model with exponential population growth, and demonstrate that the underlying ancestral process converges to a time-inhomogeneous psi-coalescent. However, by applying a nonlinear change of time scale-analogous to t

SUBMITTER: Matuszewski S 

PROVIDER: S-EPMC5753866 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature