Complex History and Differentiation Patterns of the t-Haplotype, a Mouse Meiotic Driver.

ABSTRACT: The t-haplotype, a mouse meiotic driver found on chromosome 17, has been a model for autosomal segregation distortion for close to a century, but several questions remain regarding its biology and evolutionary history. A recently published set of population genomics resources for wild mice includes several individuals heterozygous for the t-haplotype, which we use to characterize this selfish element at the genomic and transcriptomic level. Our results show that large sections of the t-haplotype have been replaced by standard homologous sequences, possibly due to occasional events of recombination, and that this complicates the inference of its history. As expected for a long genomic segment of very low recombination, the t-haplotype carries an excess of fixed n

SUBMITTER: Kelemen RK 

PROVIDER: S-EPMC5753869 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature