Improving Metabolic Health Through Precision Dietetics in Mice.

ABSTRACT: The incidence of diet-induced metabolic disease has soared over the last half-century, despite national efforts to improve health through universal dietary recommendations. Studies comparing dietary patterns of populations with health outcomes have historically provided the basis for healthy diet recommendations. However, evidence that population-level diet responses are reliable indicators of responses across individuals is lacking. This study investigated how genetic differences influence health responses to several popular diets in mice, which are similar to humans in genetic composition and the propensity to develop metabolic disease, but enable precise genetic and environmental control. We designed four human-comparable mouse diets that are representative of those eaten by historical

SUBMITTER: Barrington WT 

PROVIDER: S-EPMC5753872 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature