No association between frequent apheresis donation and risk of fractures: a retrospective cohort analysis from Sweden.

ABSTRACT:

Background

Citrate anticoagulation during apheresis induces transient alterations in calcium homeostasis. It is unknown whether the repeated, transient alterations in calcium homeostasis experienced by repeated apheresis donors affects bone turnover to increase fracture risk. Our aim was to investigate the risk of osteoporotic and nonosteoporotic fracture among voluntary, frequent apheresis donors.

Study design and methods

All apheresis donors were identified from the Scandinavian Donations and Transfusions database (SCANDAT2), which includes information on over 1.6 million blood donors from Sweden and Denmark from the years 1968 and 1981, respectively. Only data from Sweden were used for these analyses. Information on fractures was obtained by linking SCANDAT2 to hospital r

SUBMITTER: Grau K 

PROVIDER: S-EPMC5754008 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature