Hemoglobin A_1c levels and risk of sudden cardiac death: A nested case-control study.

ABSTRACT:

Background

Sudden cardiac death (SCD) is often the first manifestation of cardiovascular disease (CVD), and preventive strategies within this broad population are lacking. Patients with diabetes represent a high-risk subgroup, but few data exist regarding whether measures of glycemia mediate risk and/or add to SCD risk stratification.

Objective

The purpose of this study was to examine the association between hemoglobin A_1c (HbA_1c) and SCD.

Methods

We performed a case-control analysis among individuals enrolled in 6 prospective cohort studies. HbA_1c levels were determined for 482 cases of SCD and 914 matched controls. Conditional logistic regression with fixed effects meta-analysis was used for analysis.

Results

In multivariable

SUBMITTER: Patel RB 

PROVIDER: S-EPMC5754013 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature