Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia.

ABSTRACT: Microglia play critical roles in tissue homeostasis and can also modulate neuronal function and synaptic connectivity. In contrast to astrocytes and oligodendrocytes, which arise from multiple progenitor pools, microglia arise from yolk sac progenitors and are widely considered to be equivalent throughout the CNS. However, little is known about basic properties of deep brain microglia, such as those within the basal ganglia (BG). Here, we show that microglial anatomical features, lysosome content, membrane properties, and transcriptomes differ significantly across BG nuclei. Region-specific phenotypes of BG microglia emerged during the second postnatal week and were re-established following genetic or pharmacological microglial ablation and repopulation in the adult, indicating that local

SUBMITTER: De Biase LM 

PROVIDER: S-EPMC5754189 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature