Dataset Information

Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia.

ABSTRACT: Microglia play critical roles in tissue homeostasis and can also modulate neuronal function and synaptic connectivity. In contrast to astrocytes and oligodendrocytes, which arise from multiple progenitor pools, microglia arise from yolk sac progenitors and are widely considered to be equivalent throughout the CNS. However, little is known about basic properties of deep brain microglia, such as those within the basal ganglia (BG). Here, we show that microglial anatomical features, lysosome content, membrane properties, and transcriptomes differ significantly across BG nuclei. Region-specific phenotypes of BG microglia emerged during the second postnatal week and were re-established following genetic or pharmacological microglial ablation and repopulation in the adult, indicating that local cues play an ongoing role in shaping microglial diversity. These findings demonstrate that microglia in the healthy brain exhibit a spectrum of distinct functional states and provide a critical foundation for defining microglial contributions to BG circuit function.

SUBMITTER: De Biase LM

PROVIDER: S-EPMC5754189 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia.

De Biase Lindsay M LM Schuebel Kornel E KE Fusfeld Zachary H ZH Jair Kamwing K Hawes Isobel A IA Cimbro Raffaello R Zhang Hai-Ying HY Liu Qing-Rong QR Shen Hui H Xi Zheng-Xiong ZX Goldman David D Bonci Antonello A

Neuron 20170706 2

Microglia play critical roles in tissue homeostasis and can also modulate neuronal function and synaptic connectivity. In contrast to astrocytes and oligodendrocytes, which arise from multiple progenitor pools, microglia arise from yolk sac progenitors and are widely considered to be equivalent throughout the CNS. However, little is known about basic properties of deep brain microglia, such as those within the basal ganglia (BG). Here, we show that microglial anatomical features, lysosome conten ...[more]

PMID: 28689984

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Dataset Information

Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia.

Publications

Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia.

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