Development of a synthetic Vi polysaccharide vaccine for typhoid fever.

ABSTRACT: Typhoid fever remains a serious public health problem with a high impact on toddlers and young children. Vaccines against the Vi capsular polysaccharide are efficacious against typhoid fever demonstrating that antibodies against Vi confer protection. The currently licensed Vi typhoid vaccines have however limited efficacy and are manufactured by a complex process from wild-type bacteria. Due to these inherent issues with the current vaccines, an alternative vaccine based on an O-acetylated high molecular weight (HMW) polygalacturonic acid (GelSite-OAc™) was generated. The HMW polygalacturonic acid shares the same backbone as the Vi polysaccharide of Salmonella Typhi. The GelSite-OAc™ has a high molecular weight (>1 × 10⁶ Da) and a high degree of O-acetylation (DOAc) (>5 μmole/mg

SUBMITTER: Ni Y 

PROVIDER: S-EPMC5754192 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature