Conserved noncoding transcription and core promoter regulatory code in early Drosophila development.

ABSTRACT: Multicellular development is driven by regulatory programs that orchestrate the transcription of protein-coding and noncoding genes. To decipher this genomic regulatory code, and to investigate the developmental relevance of noncoding transcription, we compared genome-wide promoter activity throughout embryogenesis in 5 Drosophila species. Core promoters, generally not thought to play a significant regulatory role, in fact impart restrictions on the developmental timing of gene expression on a global scale. We propose a hierarchical regulatory model in which core promoters define broad windows of opportunity for expression, by defining a range of transcription factors from which they can receive regulatory inputs. This two-tiered mechanism globally orchestrates developmental gene ex

SUBMITTER: Batut PJ 

PROVIDER: S-EPMC5754203 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature