Adaptive SNP-Set Association Testing in Generalized Linear Mixed Models with Application to Family Studies.

ABSTRACT: In genome-wide association studies (GWAS), it has been increasingly recognized that, as a complementary approach to standard single SNP analyses, it may be beneficial to analyze a group of functionally related SNPs together. Among the existent population-based SNP-set association tests, two adaptive tests, the aSPU test and the aSPUpath test, offer a powerful and general approach at the gene- and pathway-levels by data-adaptively combining the results across multiple SNPs (and genes) such that high statistical power can be maintained across a wide range of scenarios. We extend the aSPU and the aSPUpath test to familial data under the framework of the generalized linear mixed models (GLMMs), which can take account of both subject relatedness and possible population structure. As in populati

SUBMITTER: Park JY 

PROVIDER: S-EPMC5754233 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature