Calcium intake and risk of colorectal cancer according to expression status of calcium-sensing receptor (CASR).

ABSTRACT:

Objective

Although evidence suggests an inverse association between calcium intake and the risk of colorectal cancer, the mechanisms remain unclear. The calcium-sensing receptor (CASR) is expressed abundantly in normal colonic epithelium and may influence carcinogenesis. We hypothesized that calcium intake might be associated with lower risk of CASR-positive, but not CASR-negative, colorectal cancer.

Design

We assessed tumour CASR protein expression using immunohistochemistry in 779 incident colon and rectal cancer cases that developed among 136 249 individuals in the Nurses' Health Study and Health Professionals Follow-Up Study. Duplication method Cox proportional hazards regression analysis was used to assess associations of calcium intake with incidence of colorectal aden

SUBMITTER: Yang W 

PROVIDER: S-EPMC5754263 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature