Fifty Years of Research in ARDS. Vt Selection in Acute Respiratory Distress Syndrome.

ABSTRACT: Mechanical ventilation (MV) is critical in the management of many patients with acute respiratory distress syndrome (ARDS). However, MV can also cause ventilator-induced lung injury (VILI). The selection of an appropriate Vt is an essential part of a lung-protective MV strategy. Since the publication of a large randomized clinical trial demonstrating the benefit of lower Vts, the use of Vts of 6 ml/kg predicted body weight (based on sex and height) has been recommended in clinical practice guidelines. However, the predicted body weight approach is imperfect in patients with ARDS because the amount of aerated lung varies considerably due to differences in inflammation, consolidation, flooding, and atelectasis. Better approaches to setting Vt may include limits on end-inspiratory transpulmon

SUBMITTER: Sahetya SK 

PROVIDER: S-EPMC5754449 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature