Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis.

ABSTRACT: Inflammatory illness is associated with depression. Preclinical work has shown that chemokines are linked with peripheral-central crosstalk and may be important in mediating depressive behaviours. We sought to establish what evidence exists that differences in blood or cerebrospinal fluid chemokine concentration discriminate between individuals with depression and those without. Following PRISMA guidelines, we systematically searched Embase, PsycINFO and Medline databases. We included participants with physical illness for subgroup analysis, and excluded participants with comorbid psychiatric diagnoses. Seventy-three studies met the inclusion criteria for the meta-analysis. Individuals with depression had higher levels of blood CXCL4 and CXCL7 and lower levels of blood CCL4. Sensitivity an

SUBMITTER: Leighton SP 

PROVIDER: S-EPMC5754468 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature