Safety and tolerability of one-year intramuscular testosterone regime to induce puberty in older men with CHH.

ABSTRACT: We present herein our 20-year experience of pubertal induction in apubertal older (median age 56 years; range 38.4-69.5) men with congenital hypogonadotrophic hypogonadism (n = 7) using a simple fixed-dose and fixed-interval intramuscular testosterone that we originally pioneered in relation to achieving virilisation of natal female transgender men. This regime was effective and well tolerated, resulting in complete virilisation by around 1 year after treatment initiation. No physical or psychological adverse effects were encountered in this group of potentially vulnerable individuals. There were no abnormal excursions of laboratory parameters and extended follow-up beyond the first year of treatment revealed remarkable improvements in bone density. We highlight advantages to both patients

SUBMITTER: Pazderska A 

PROVIDER: S-EPMC5754506 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature