Evolutionary dynamics in the two-locus two-allele model with weak selection.

ABSTRACT: Two-locus two-allele models are among the most studied models in population genetics. The reason is that they are the simplest models to explore the role of epistasis for a variety of important evolutionary problems, including the maintenance of polymorphism and the evolution of genetic incompatibilities. Many specific types of models have been explored. However, due to the mathematical complexity arising from the fact that epistasis generates linkage disequilibrium, few general insights have emerged. Here, we study a simpler problem by assuming that linkage disequilibrium can be ignored. This is a valid approximation if selection is sufficiently weak relative to recombination. The goal of our paper is to characterize all possible equilibrium structures, or more precisely and general, all

SUBMITTER: Pontz M 

PROVIDER: S-EPMC5754571 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature