Gα_s protein binds ubiquitin to regulate epidermal growth factor receptor endosomal sorting.

ABSTRACT: The Gα_s subunit is classically involved in the signal transduction of G protein-coupled receptors (GPCRs) at the plasma membrane. Recent evidence has revealed noncanonical roles for Gα_s in endosomal sorting of receptors to lysosomes. However, the mechanism of action of Gα_s in this sorting step is still poorly characterized. Here, we report that Gα_s interacts with ubiquitin to regulate the endosomal sorting of receptors for lysosomal degradation. We reveal that the N-terminal extremity of Gα_s contains a ubiquitin-interacting motif (UIM), a sorting element usually found in the endosomal sorting complex required for transport (ESCRT) machinery responsible for sorting ubiquitinated receptors into intraluminal vesicles (ILVs) of multivesicu

SUBMITTER: Li X 

PROVIDER: S-EPMC5754765 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature