Ontology highlight
ABSTRACT:
SUBMITTER: Tavares AJ
PROVIDER: S-EPMC5754793 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Tavares Anthony J AJ Poon Wilson W Zhang Yi-Nan YN Dai Qin Q Besla Rickvinder R Ding Ding D Ouyang Ben B Li Angela A Chen Juan J Zheng Gang G Robbins Clinton C Chan Warren C W WCW
Proceedings of the National Academy of Sciences of the United States of America 20171205 51
A recent metaanalysis shows that 0.7% of nanoparticles are delivered to solid tumors. This low delivery efficiency has major implications in the translation of cancer nanomedicines, as most of the nanomedicines are sequestered by nontumor cells. To improve the delivery efficiency, there is a need to investigate the quantitative contribution of each organ in blocking the transport of nanoparticles to solid tumors. Here, we hypothesize that the removal of the liver macrophages, cells that have bee ...[more]