STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo.

ABSTRACT: Regulated mesoderm migration is necessary for the proper morphogenesis and organ formation during embryonic development. Cell migration and its dependence on the cytoskeleton and signaling machines have been studied extensively in cultured cells; in contrast, remarkably little is known about the mechanisms that regulate mesoderm cell migration in vivo. Here, we report the identification and characterization of a mouse mutation in striatin-interacting protein 1 (Strip1) that disrupts migration of the mesoderm after the gastrulation epithelial-to-mesenchymal transition (EMT). STRIP1 is a core component of the biochemically defined mammalian striatin-interacting phosphatases and kinase (STRIPAK) complexes that appear to act through regulation of protein phosphatase 2A (PP2A), but their

SUBMITTER: Bazzi H 

PROVIDER: S-EPMC5754794 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature