Impact of the HIV-1 genetic background and HIV-1 population size on the evolution of raltegravir resistance.

ABSTRACT: BACKGROUND:Emergence of resistance against integrase inhibitor raltegravir in human immunodeficiency virus type 1 (HIV-1) patients is generally associated with selection of one of three signature mutations: Y143C/R, Q148K/H/R or N155H, representing three distinct resistance pathways. The mechanisms that drive selection of a specific pathway are still poorly understood. We investigated the impact of the HIV-1 genetic background and population dynamics on the emergence of raltegravir resistance. Using deep sequencing we analyzed the integrase coding sequence (CDS) in longitudinal samples from five patients who initiated raltegravir plus optimized background therapy at viral loads > 5000 copies/ml. To investigate the role of the HIV-1 genetic background we created recombinant viruses containi

SUBMITTER: Fun A 

PROVIDER: S-EPMC5755036 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature