Inflammatory monocytes expressing tissue factor drive SIV and HIV coagulopathy.

ABSTRACT: In HIV infection, persistent inflammation despite effective antiretroviral therapy is linked to increased risk of noninfectious chronic complications such as cardiovascular and thromboembolic disease. A better understanding of inflammatory and coagulation pathways in HIV infection is needed to optimize clinical care. Markers of monocyte activation and coagulation independently predict morbidity and mortality associated with non-AIDS events. We identified a specific subset of monocytes that express tissue factor (TF), persist after virological suppression, and trigger the coagulation cascade by activating factor X. This subset of monocytes expressing TF had a distinct gene signature with up-regulated innate immune markers and evidence of robust production of multiple proinflammatory cytokin

SUBMITTER: Schechter ME 

PROVIDER: S-EPMC5755598 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature