PKCε Controls Mitotic Progression by Regulating Centrosome Migration and Mitotic Spindle Assembly.

ABSTRACT: To form a proper mitotic spindle, centrosomes must be duplicated and driven poleward in a timely and controlled fashion. Improper timing of centrosome separation and errors in mitotic spindle assembly may lead to chromosome instability, a hallmark of cancer. Protein kinase C epsilon (PKCε) has recently emerged as a regulator of several cell-cycle processes associated with the resolution of mitotic catenation during the metaphase-anaphase transition and in regulating the abscission checkpoint. However, an engagement of PKCε in earlier (pre)mitotic events has not been addressed. Here, we now establish that PKCε controls prophase-to-metaphase progression by coordinating centrosome migration and mitotic spindle assembly in transformed cells. This control is exerted through cytoplasmic dynein f

SUBMITTER: Martini S 

PROVIDER: S-EPMC5755688 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature