Abyssomicin 2 reactivates latent HIV-1 by a PKC- and HDAC-independent mechanism.

ABSTRACT: Screening of a marine natural products library afforded three new analogues of the tetronic acid containing polyketide abyssomicin family and identified abyssomicin 2 as a selective reactivator of latent HIV virus. Examination of the mode of action of this new latent HIV reactivating agent demonstrated that it functions via a distinct mechanism compared to that of existing reactivating agents and is effective at reactivating latent virus in a subset of primary patient cell lines.

SUBMITTER: Leon B 

PROVIDER: S-EPMC5755699 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature