White matter alterations in Parkinson's disease with normal cognition precede grey matter atrophy.

ABSTRACT:

Introduction

While progressive MRI brain changes characterize advanced Parkinson's disease (PD), little has been discovered about structural alterations in the earliest phase of the disease, i.e. in patients with motor symptoms and with normal cognition. Our study aimed to detect grey matter (GM) and white matter (WM) changes in PD patients without cognitive impairment.

Methods

Twenty PD patients and twenty-one healthy controls (HC) were tested for attention, executive function, working memory, and visuospatial and language domains. High-resolution T1-weighted and 60 directional diffusion-weighted 3T MRI images were acquired. The cortical, deep GM and WM volumes and density, as well as the diffusion properties of WM, were calculated. Analyses were repeated on data flipped to

SUBMITTER: Rektor I 

PROVIDER: S-EPMC5755732 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature