Severe hyposmia and aberrant functional connectivity in cognitively normal Parkinson's disease.

ABSTRACT:

Objective

Severe hyposmia is a risk factor of dementia in Parkinson's disease (PD), while the underlying functional connectivity (FC) and brain volume alterations in PD patients with severe hyposmia (PD-SH) are unclear.

Methods

We examined voxel-based morphometric and resting state functional magnetic resonance imaging findings in 15 cognitively normal PD-SH, 15 cognitively normal patients with PD with no/mild hyposmia (PD-N/MH), and 15 healthy controls (HCs).

Results

Decreased gray matter volume (GMV) was observed in the bilateral cuneus, right associative visual area, precuneus, and some areas in anterior temporal lobes in PD-SH group compared to HCs. Both the PD-SH and PD-N/MH groups showed increased GMV in the bilateral posterior insula and its surrounding regions

SUBMITTER: Yoneyama N 

PROVIDER: S-EPMC5755765 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature