Hyperleptinemia positively associated with central arterial stiffness in hemodialysis patients.

ABSTRACT:

Objective

Leptin plays a role in stimulating vascular inflammation, vascular smooth muscle hypertrophy, and augmenting blood pressure, which contributes to the pathogenesis of atherosclerosis and leads to arterial stiffness. This vascular damage, measured by carotid-femoral pulse wave velocity (cfPWV), is recognized as an independent predictor of cardiovascular mortality in hemodialysis (HD) patients. The aim of this study was to evaluate the relationship between serum leptin and arterial stiffness in HD patients.

Patients and methods

In 112 of the 126 HD patients were eligible and their biochemical data were collected for analysis. Serum leptin level was measured using a commercial enzyme-linked immunosorbent assay kit. Carotid-femoral pulse wave velocity was measured by a

SUBMITTER: Kuo CH 

PROVIDER: S-EPMC5755912 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature