Sulfite-induced protein radical formation in LPS aerosol-challenged mice: Implications for sulfite sensitivity in human lung disease.

ABSTRACT: Exposure to (bi)sulfite (HSO₃^-) and sulfite (SO₃^2-) has been shown to induce a wide range of adverse reactions in sensitive individuals. Studies have shown that peroxidase-catalyzed oxidation of (bi)sulfite leads to formation of several reactive free radicals, such as sulfur trioxide anion (.SO₃^-), peroxymonosulfate (^-O₃SOO.), and especially the sulfate (SO₄^{. -}) anion radicals. One such peroxidase in neutrophils is myeloperoxidase (MPO), which has been shown to form protein radicals. Although formation of (bi)sulfite-derived protein radicals is documented in isolated neutrophils, its involvement and role in in vivo inflammatory processes, has not been demonstrated. Therefore, we ai

SUBMITTER: Kumar A 

PROVIDER: S-EPMC5756054 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature