Use of Pulsed Low-Dose Rate Radiotherapy in Refractory Malignancies.

ABSTRACT:

Background

Most tumor cell lines exhibited low-dose hyperradiosensitivity (LDHRS) to radiation doses lower than 0.3 Gy. Pulsed low-dose rate radiotherapy (PLDR) took advantage of LDHRS and maximized the tumor control process. In this study, we retrospectively analyzed patients receiving PLDR for refractory malignancies.

Patients and methods

In total, 22 patients were included in our study: 9 females and 13 males. The median age was 61 years old. All the patients previously received multiline treatments and failed with an estimated survival less than 6 months. Thus, palliative PLDR was given. The PLDR was delivered using 10 fractions of 2 Gy/day, with an interval of 3 minutes, for 5 days per week. The dose rate was 6.67 cGy/min. The median follow-up was 1 year (range 8-30 mon

SUBMITTER: Yan J 

PROVIDER: S-EPMC5756059 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature