Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice.

ABSTRACT: The mouse strain SKH1 is widely used in skin research due to its hairless phenotype and intact immune system. Due to the complex nature of aryl hydrocarbon receptor (AHR) function in the skin, the development of additional in vivo models is necessary to study its role in cutaneous homeostasis and pathology. Variants of the Ah allele, exist among different mouse strains. The Ah^b-1 and Ah^d alleles express high and low affinity ligand binding forms of the AHR, respectively. The outbred SKH1 mice express the Ah^b-2 and/or Ah^d alleles. SKH1 mice were crossed with C57BL/6J mice, which harbor the Ah^b-1 allele, to create useful models for studying endogenous AHR function. SKH1 mice were bred to be homozygous for either the Ah^b-1 or A

SUBMITTER: Smith KJ 

PROVIDER: S-EPMC5756104 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature