Orchestration of H3K27 methylation: mechanisms and therapeutic implication.

ABSTRACT: Histone proteins constitute the core component of the nucleosome, the basic unit of chromatin. Chemical modifications of histone proteins affect their interaction with genomic DNA, the accessibility of recognized proteins, and the recruitment of enzymatic complexes to activate or diminish specific transcriptional programs to modulate cellular response to extracellular stimuli or insults. Methylation of histone proteins was demonstrated 50 years ago; however, the biological significance of each methylated residue and the integration between these histone markers are still under intensive investigation. Methylation of histone H3 on lysine 27 (H3K27) is frequently found in the heterochromatin and conceives a repressive marker that is linked with gene silencing. The identification of enzymes t

SUBMITTER: Pan MR 

PROVIDER: S-EPMC5756243 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature