A powerful parent-of-origin effects test for qualitative traits on X chromosome in general pedigrees.

ABSTRACT:

Background

Genomic imprinting is one of the well-known epigenetic factors causing the association between traits and genes, and has generally been examined by detecting parent-of-origin effects of alleles. A lot of methods have been proposed to test for parent-of-origin effects on autosomes based on nuclear families and general pedigrees. Although these parent-of-origin effects tests on autosomes have been available for more than 15 years, there has been no statistical test developed to test for parent-of-origin effects on X chromosome, until the parental-asymmetry test on X chromosome (XPAT) and its extensions were recently proposed. However, these methods on X chromosome are only applicable to nuclear families and thus are not suitable for general pedigrees.

Results

In thi

SUBMITTER: Zou QL 

PROVIDER: S-EPMC5756386 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature