The association between pre-miR-27a rs895819 polymorphism and myocardial infarction risk in a Chinese Han population.

ABSTRACT:

Background

Accumulating evidences have shown that miRNAs are directly or indirectly involved in a variety of biological processes, and closely associated with diverse human diseases, including cardiovascular diseases. SNPs locating within pri/pre-miRNA can affect miRNA processing and binding ability of target genes. MiR-27a, miR-26a-1 miR-100, miR-126 and miR-218 were reported to be associated with pathogenesis of myocardial infarction (MI). Here we aimed to evaluate the potential association of five polymorphisms in these pri/pre-miRNAs with individual susceptibility to MI in a Chinese Han population.

Methods

Genotyping was performed in 287 MI cases and 646 control subjects using polymerase chain reaction-ligase detection reaction (PCR-LDR) method. The association of these

SUBMITTER: Cai MY 

PROVIDER: S-EPMC5756394 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature