The SNP rs10911021 is associated with oxidative stress in coronary heart disease patients from Pakistan.

ABSTRACT:

Background

rs10911021 (a single nucleotide polymorphism present upstream of the GLUL gene) affects glutamic acid metabolism, and was shown to be associated with coronary heart disease (CHD) in patients with T2DM but a definite mechanism is unknown. It may affect glutathione cycle, an important effector in the antioxidant defense mechanism, in the cells. We checked the association of this SNP with CHD and oxidative stress biomarkers, malondialdeheyde (MDA), GSH and GSSG in Pakistani patients.

Methods

A total of 650 subjects (425 CHD cases and 225 controls) were genotyped by TaqMan allelic discrimination technique. The levels of MDA, GSH and GSSG were measured by standard protocols.

Results

The risk allele frequency was higher in cases than controls, but the difference

SUBMITTER: Shahid SU 

PROVIDER: S-EPMC5756419 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature