Emerging Diagnostic and Therapeutic Strategies for Tauopathies.

ABSTRACT:

Purpose of review

Tauopathies represent a spectrum of incurable and progressive age-associated neurodegenerative diseases that currently are diagnosed definitively only at autopsy. Few clinical diagnoses, such as classic Richardson's syndrome of progressive supranuclear palsy, are specific for underlying tauopathy and no clinical syndrome is fully sensitive to reliably identify all forms of clinically manifest tauopathy. Thus, a major unmet need for the development and implementation of tau-targeted therapies is precise antemortem diagnosis. This article reviews new and emerging diagnostic therapies for tauopathies including novel imaging techniques and biomarkers and also reviews recent tau therapeutics.

Recent findings

Building evidence from animal and cell models suggests

SUBMITTER: Coughlin D 

PROVIDER: S-EPMC5756477 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature