Sequencing rare marine actinomycete genomes reveals high density of unique natural product biosynthetic gene clusters.

ABSTRACT: Traditional natural product discovery methods have nearly exhausted the accessible diversity of microbial chemicals, making new sources and techniques paramount in the search for new molecules. Marine actinomycete bacteria have recently come into the spotlight as fruitful producers of structurally diverse secondary metabolites, and remain relatively untapped. In this study, we sequenced 21 marine-derived actinomycete strains, rarely studied for their secondary metabolite potential and under-represented in current genomic databases. We found that genome size and phylogeny were good predictors of biosynthetic gene cluster diversity, with larger genomes rivalling the well-known marine producers in the Streptomyces and Salinispora genera. Genomes in the Micrococcineae suborder, however, had co

SUBMITTER: Schorn MA 

PROVIDER: S-EPMC5756490 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature