Role of microRNAs in doxorubicin-induced cardiotoxicity: an overview of preclinical models and cancer patients.

ABSTRACT: Cardiotoxicity is a well-known side effect of doxorubicin (DOX), but the mechanisms leading to this phenomenon are still not completely clear. Prediction of drug-induced dysfunction onset is difficult and is still largely based on detection of cardiac troponin (cTn), a circulating marker of heart damage. In the last years, several investigations focused on the possible involvement of microRNAs (miRNAs) in DOX-induced toxicity in vitro, with contrasting results. Recently, several groups employed animal models to mimic patient's condition, investigate the biological pathways perturbed by DOX, and identify diagnostic markers of cardiotoxicity. We reviewed the results from several studies investigating cardiac miRNAs expression in rodent models of DOX-treatment. We also discussed the data from

SUBMITTER: Ruggeri C 

PROVIDER: S-EPMC5756562 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature