The Contribution of MMP-8 Promoter Genotypes to Childhood Leukemia.

ABSTRACT:

Background/aim

Accumulated evidence has supported the notion that matrix metalloproteinase (MMP) genotypes are associated with the susceptibility of many types of cancers. However, few reports have studied the contribution of MMP genotypes to either diagnostic or prognostic potential in non-solid tumors such as leukemia. In this study, we firstly investigated the contribution of a polymorphism in the promoter region of MMP-8 (-799C/T) and two non-synonymous polymorphisms (Val436Ala and Lys460Thr) to childhood leukemia.

Patients and methods

In this study, 266 patients with childhood acute lymphoblastic leukemia (ALL) and 266 non-cancer control patients were collected and the genomic DNA was isolated from their peripheral blood. MMP-8 -799C/T, Val436Ala and Lys460Thr polymorph

SUBMITTER: Pei JS 

PROVIDER: S-EPMC5756632 | biostudies-literature | 2017 Nov-Dec

REPOSITORIES: biostudies-literature