Oxoiron(IV) complexes as synthons for the assembly of heterobimetallic centers such as the Fe/Mn active site of Class Ic ribonucleotide reductases.

ABSTRACT: Nonheme oxoiron(IV) complexes can serve as synthons for generating heterobimetallic oxo-bridged dimetal complexes by reaction with divalent metal complexes. The formation of Fe^III-O-Cr^III and Fe^III-O-Mn^III complexes is described herein. The latter complexes may serve as models for the Fe^III-X-Mn^III active sites of an emerging class of Fe/Mn enzymes represented by the Class 1c ribonucleotide reductase from Chlamydia trachomatis and the R2-like ligand-binding oxidase (R2lox) found in Mycobacterium tuberculosis. These synthetic complexes have been characterized by UV-Vis, resonance Raman, and X-ray absorption spectroscopy, as well as electrospray mass spectrometry. The Fe^III-O-Cr^III complexes exhibit a thr

SUBMITTER: Zhou A 

PROVIDER: S-EPMC5756673 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature