Exposure to permethrin promotes high fat diet-induced weight gain and insulin resistance in male C57BL/6J mice.

ABSTRACT: Permethrin is a pyrethroid pesticide that was previously reported to promote fat accumulation and insulin resistance in vitro. A recent study in female mice also found that permethrin could promote high fat-induced insulin resistance. The effects of permethrin on glucose and lipid metabolisms in male mice, however, remain unknown. The purpose of this study was to investigate the effects and interactions of permethrin exposure (50, 500, and 5000 μg/kg body weight/day) and dietary fat (low fat, 4% w/w; high fat, 20% w/w) on development of obesity and insulin resistance in male C57BL/6J mice. Our results showed that permethrin treatment significantly increased body weight, fat mass, and insulin resistance with high fat diet, but not with low fat diet, without influencing energy intake. Permet

SUBMITTER: Xiao X 

PROVIDER: S-EPMC5756676 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature