Decreased neurite density within frontostriatal networks is associated with executive dysfunction in temporal lobe epilepsy.

ABSTRACT:

Objective

Executive dysfunction is observed in a sizable number of patients with refractory temporal lobe epilepsy (TLE). The frontostriatal network has been proposed to play a significant role in executive functioning, however, because of the complex architecture of these tracts, it is difficult to generate measures of fiber tract microstructure using standard diffusion tensor imaging. To examine the association between frontostriatal network compromise and executive dysfunction in TLE, we applied an advanced, multishell diffusion model, restriction spectrum imaging (RSI), that isolates measures of intraaxonal diffusion and may provide better estimates of fiber tract compromise in TLE.

Methods

Restriction spectrum imaging scans were obtained from 32 patients with TLE [16 ri

SUBMITTER: Reyes A 

PROVIDER: S-EPMC5756677 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature