Metabolic Footprints and Molecular Subtypes in Breast Cancer.

ABSTRACT: Cancer treatment options are increasing. However, even among the same tumor histotype, interpatient tumor heterogeneity should be considered for best therapeutic result. Metabolomics represents the last addition to promising "omic" sciences such as genomics, transcriptomics, and proteomics. Biochemical transformation processes underlying energy production and biosynthetic processes have been recognized as a hallmark of the cancer cell and hold a promise to build a bridge between genotype and phenotype. Since breast tumors represent a collection of different diseases, understanding metabolic differences between molecular subtypes offers a way to identify new subtype-specific treatment strategies, especially if metabolite changes are evaluated in the broader context of the network of enzymat

SUBMITTER: Cappelletti V 

PROVIDER: S-EPMC5757146 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature