Curcumin and Natural Derivatives Inhibit Ebola Viral Proteins: An In silico Approach.

ABSTRACT:

Background

Ebola viral disease is a severe and mostly fatal disease in humans caused by Ebola virus. This virus belongs to family Filoviridae and is a single-stranded negative-sense virus. There is no single treatment for this disease which puts forth the need to identify new therapy to control and treat this fatal condition. Curcumin, one of the bioactives of turmeric, has proven antiviral property.

Objective

The current study evaluates the inhibitory activity of curcumin, bisdemethoxycurcumin, demethoxycurcumin, and tetrahydrocurcumin against Zaire Ebola viral proteins (VPs).

Materials and methods

Molecular simulation of the Ebola VPs followed by docking studies with ligands comprising curcumin and related compounds was performed.

Results

The highest b

SUBMITTER: Baikerikar S 

PROVIDER: S-EPMC5757320 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature